Real cases.
Real experiences. 

From your peers.

Learn about Cobenfy from experts

Real-World Cases and Experience: Integrating COBENFY Into Your Practice

Join national experts as they share practical insights on incorporating COBENFY into clinical practice. This video series, featuring Dr Craig Chepke, Dr Lara G. Shirikjian, and Brooke Kempf, PMHNP-BC, is designed to guide you through identifying appropriate patients, initiating treatment, and addressing common questions.

To gain a comprehensive perspective on patient care strategies, the COBENFY data, and best practices for integration into your practice, please watch the videos below in order and in their entirety.

Watch video: identify appropriate patients for Cobenfy

Identifying Appropriate COBENFY Patients

Dr Chepke, Dr Shirikjian, and Ms Kempf discuss practical strategies for identifying patients who may benefit from a treatment change. Learn how to recognize key clinical features and apply patient-centered care approaches.

11:53

Watch video: data on Cobenfy and initiation into clinical practice

Early Data and Real World Insights

Explore efficacy and safety data on COBENFY and hear how KOLs approach early integration into practice. They share patient cases highlighting key considerations when introducing COBENFY into treatment discussions.

16:50

Watch video: practical considerations when initiating Cobenfy

Integrating COBENFY into Your Practice

Gain actionable insights into initiating COBENFY, from starting doses to monitoring. The experts discuss patient selection, dosing considerations, and their implementation strategies using real-world cases.

20:52

Watch video: addressing common questions about Cobenfy

Addressing Common Questions

The panel answers frequently asked questions about COBENFY, covering practical issues like patient counseling, monitoring strategies, and addressing common questions.

12:50

Cobenfy titration and sample packs

Ready to get your patients started with COBENFY?

COBENFY Efficacy, Safety Profile, and More—Explained by Clinical Experts

Learn from your peers as they discuss the efficacy, safety, and mechanism of action of COBENFY— along with practical strategies for initiating treatment and supporting patients.

Watch video: Gerald A. Maguire, MD explains the efficacy data of Cobenfy

Short- and Long-Term Efficacy Data with COBENFY

Review of the COBENFY efficacy assessed across symptom domains in short- and long-term trials in adult schizophrenia patients.

16:52

Watch video: Jelena Kunovac, MD on the safety profile of Cobenfy

Safety and Tolerability of COBENFY

The safety and tolerability profile of COBENFY was evaluated in over 1250 patients in 5 trials.

17:11

Watch video: Nurse Practitioner Hara Oyedeji talks about getting patients started on Cobenfy

Getting Patients Started on COBENFY

Insights on starting COBENFY, including dose titration, monitoring, and key drug interactions.

14:34

Watch video: Gus Alva, MD explains the mechanism of action (MOA) of Cobenfy

COBENFY Mechanism of Action

Overview of the composition for COBENFY—xanomeline and trospium chloride—and its proposed mechanism of action.

12:43

Explore the efficacy data
of COBENFY

Explore dosing
for COBENFY

IMPORTANT SAFETY INFORMATION

CONTRAINDICATIONS

COBENFY™ is contraindicated in patients with: urinary retention; moderate or severe (Child-Pugh Class B or C) hepatic impairment; gastric retention; history of hypersensitivity to COBENFY or trospium chloride—angioedema has been reported with COBENFY and trospium chloride; and untreated narrow-angle glaucoma.

WARNINGS AND PRECAUTIONS

Risk of Urinary Retention: COBENFY can cause urinary retention. Geriatric patients and patients with clinically significant bladder outlet obstruction and incomplete bladder emptying (e.g., patients with benign prostatic hyperplasia (BPH), diabetic cystopathy) may be at increased risk of urinary retention.

COBENFY is contraindicated in patients with pre-existing urinary retention and is not recommended in patients with moderate or severe renal impairment.

In patients taking COBENFY, monitor for symptoms of urinary retention, including urinary hesitancy, weak stream, incomplete bladder emptying, and dysuria. Instruct patients to be aware of the risk and promptly report symptoms of urinary retention to their healthcare provider. Urinary retention is a known risk factor for urinary tract infections. In patients with symptoms of urinary retention, consider reducing the dose of COBENFY, discontinuing COBENFY, or referring patients for urologic evaluation as clinically indicated.

Risk of Use in Patients with Hepatic Impairment: Patients with hepatic impairment have higher systemic exposures of xanomeline, a component of COBENFY, compared to patients with normal hepatic function, which may result in increased incidence of COBENFY-related adverse reactions.

COBENFY is contraindicated in patients with moderate or severe hepatic impairment. COBENFY is not recommended in patients with mild hepatic impairment.

Assess liver enzymes prior to initiating COBENFY and as clinically indicated during treatment.

Risk of Use in Patients with Biliary Disease: In clinical studies with COBENFY, transient increases in liver enzymes with rapid decline occurred, consistent with transient biliary obstruction due to biliary contraction and possible gallstone passage.

COBENFY is not recommended for patients with active biliary disease such as symptomatic gallstones. Assess liver enzymes and bilirubin prior to initiating COBENFY and as clinically indicated during treatment. The occurrence of symptoms such as dyspepsia, nausea, vomiting, or upper abdominal pain should prompt assessment for gallbladder disorders, biliary disorders, and pancreatitis, as clinically indicated.

Discontinue COBENFY in the presence of signs or symptoms of substantial liver injury such as jaundice, pruritus, or alanine aminotransferase levels more than five times the upper limit of normal or five times baseline values.

Decreased Gastrointestinal Motility: COBENFY contains trospium chloride. Trospium chloride, like other antimuscarinic agents, may decrease gastrointestinal motility. Administer COBENFY with caution in patients with gastrointestinal obstructive disorders because of the risk of gastric retention. Use COBENFY with caution in patients with conditions such as ulcerative colitis, intestinal atony, and myasthenia gravis.

Risk of Angioedema: Angioedema of the face, lips, tongue, and/or larynx has been reported with COBENFY and trospium chloride, a component of COBENFY. In one case, angioedema occurred after the first dose of trospium chloride. Angioedema associated with upper airway swelling may be life-threatening. If involvement of the tongue, hypopharynx, or larynx occurs, discontinue COBENFY and initiate appropriate therapy and/or measures necessary to ensure a patent airway. COBENFY is contraindicated in patients with a history of hypersensitivity to trospium chloride.

Risk of Use in Patients with Narrow-angle Glaucoma: Pupillary dilation may occur due to the anticholinergic effects of COBENFY. This may trigger an acute angle closure attack in patients with anatomically narrow angles. In patients known to have anatomically narrow angles, COBENFY should only be used if the potential benefits outweigh the risks and with careful monitoring.

Increases in Heart Rate: COBENFY can increase heart rate. Assess heart rate at baseline and as clinically indicated during treatment with COBENFY.

Anticholinergic Adverse Reactions in Patients with Renal Impairment: Trospium chloride, a component of COBENFY, is substantially excreted by the kidney. COBENFY is not recommended in patients with moderate or severe renal impairment (estimated glomerular filtration rate (eGFR) <60 mL/min). Systemic exposure of trospium chloride is higher in patients with moderate and severe renal impairment. Therefore, anticholinergic adverse reactions (including dry mouth, constipation, dyspepsia, urinary tract infection, and urinary retention) are expected to be greater in patients with moderate and severe renal impairment.

Central Nervous System Effects: Trospium chloride, a component of COBENFY, is associated with anticholinergic central nervous system (CNS) effects. A variety of CNS anticholinergic effects have been reported with trospium chloride, including dizziness, confusion, hallucinations, and somnolence. Monitor patients for signs of anticholinergic CNS effects, particularly after beginning treatment or increasing the dose. Advise patients not to drive or operate heavy machinery until they know how COBENFY affects them. If a patient experiences anticholinergic CNS effects, consider dose reduction or drug discontinuation.

Most Common Adverse Reactions (≥5% and at least twice placebo): nausea, dyspepsia, constipation, vomiting, hypertension, abdominal pain, diarrhea, tachycardia, dizziness, and gastroesophageal reflux disease.

Use in Specific Populations:

 
  • Moderate or Severe Renal Impairment: Not recommended
  • Mild Hepatic Impairment: Not recommended

Pregnancy and Lactation: There is a pregnancy exposure registry that monitors outcomes in women exposed to psychiatric medications, including COBENFY, during pregnancy. Healthcare providers are encouraged to advise patients to register by calling 1-866-961-2388 or visiting https://womensmentalhealth.org/research/pregnancyregistry/atypicalantipsychotic/.

There are no available data on COBENFY use in pregnant women to evaluate for a drug-associated risk of major birth defects, miscarriage, or other adverse maternal or fetal outcomes. Additionally, there are no data on the presence of xanomeline or trospium in human milk, the effects on the breastfed infant, or the effects on milk production. However, xanomeline and trospium are present in animal milk, suggesting they may also be present in human milk. The developmental and health benefits of breastfeeding should be considered along with the mother’s clinical need for COBENFY and any potential adverse effects on the breastfed infant from COBENFY or the underlying maternal condition.

COBENFY (xanomeline and trospium chloride) is available in 50mg/20mg, 100mg/20mg, and 125mg/30mg capsules.

INDICATION

COBENFY™ (xanomeline and trospium chloride) is indicated for the treatment of schizophrenia in adults.

Please see U.S. Full Prescribing Information, including Patient Information.

1629-US-2500496 06/25

Cobenfy, Cobenfy Cares, and the Cobenfy logo are trademarks of Karuna Therapeutics, Inc., a Bristol Myers Squibb company.
© 2025 Bristol-Myers Squibb Company. 1629-US-2400140 02/25

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